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Posted by john on July 9th, 2007 — in Nasonex News
For the estimated 12 million Americans who suffer from food allergies, eating can be quite an adventure.
Just ask Chris Paganelli, 54, who has been allergic to eggs and chicken since childhood.
“I always joke that I am not very much fun to go out to a new restaurant with, because I end up being pretty neurotic,'’ the pharmaceutical rep and father of two says.
Can you blame him? At a recent business conference in Chicago, Paganelli informed the organizers in advance of his allergies. So he thought it was safe to eat what appeared to be mozzarella on his luncheon salad. About 10 minutes later, Paganelli became violently ill. That’s when he realized he had accidentally consumed a large helping of chopped, boiled egg whites.
Like many with food allergies, Paganelli has learned the hard way to be prepared. He reached for his emergency medical kit and quickly jabbed himself with an auto injector of epinephrine to reverse the anaphylactic shock, which can be fatal in minutes. Despite his best efforts to protect himself, Paganelli says most people still don’t think that food allergies are “that big a deal.'’
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Tell that to the 30,000 people who are sent to emergency rooms each year for food allergy attacks, which also claim between 100 to 200 lives annually, according to a new report from the National Institute of Allergy and Infectious Diseases. If it seems as if food allergies are on the rise, it’s not your imagination.
“For reasons that we don’t understand, the prevalence of food allergies has doubled in the last 15 years,'’ notes Wesley Burks, chief of allergy and immunology at Duke University Medical Center. In its report, the Allergy and Infectious Diseases Institute calls food allergies an emerging and “important public health problem.'’
During a food allergy attack, the immune system overreacts to some food proteins by producing too much immunoglobulin E. That sets in motion a series of reactions that can produce anything from hives and a runny nose to a full-blown, life-threatening attack.
The severity of the reaction varies according to how many times the offending food has been eaten, how much is consumed and the genetic makeup of the food-allergy sufferer. Some of the most severe attacks occur from eating peanuts and tree nuts such as cashews.
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The report notes that about 4 percent of adults and 8 percent of children ages 2 and younger, suffer from food allergies. The good news: Many will outgrow their allergies.
That’s already started to happen for Gavin Perkins, 1, of West Hartford, Conn. His wheat allergy seems to have disappeared, although he’s still allergic to chicken, eggs, dairy products, soy and fish. Since Gavin breastfeeds, that means his mother, Lisa, has to be very careful about what she eats, because food proteins pass through breast milk.
“I can’t rely on a lot of processed foods, because soy and dairy are in almost everything,'’ she says.
Food allergies are diagnosed by using blood and skin tests - coupled with a physical exam and a history of food-related problems.
Any food can produce an allergy, but milk, eggs, peanuts, tree nuts, fish, shellfish, soy and wheat account for about 90 percent of the reactions in the United States.
For now, avoidance is the only way to control food allergies. Since January 2006, the Food and Drug Administration has required food manufacturers to list leading food ingredients that can cause allergies and to note if products are produced on equipment that may contain residues of other allergy-causing foods, such as peanuts or soy.
But a study published last week suggests that the warnings are used so frequently that “consumers assume they are not serious,'’ notes the study’s co-author, Scott Sicherer of the Jaffe Food Allergy Institute at Mount Sinai School of Medicine in New York.
The study also found that the warnings “do not reflect the degree of danger'’ for those with food allergies.
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Posted by john on July 6th, 2007 — in Nasonex News
If you have a food allergy, a new study suggests it’s time to pay closer attention. Some 12-million Americans are allergic to at least one type of food, and a growing number of them are ignoring advisory warnings that appear on food labels.
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Researchers said just 75% of food allergy sufferers in 2006 heeded the advisory warnings. That’s down from 85% in 2005.
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Posted by john on July 2nd, 2007 — in Nasonex News
Interleukin-12 has been shown to be “missing” in mice which were bred to be allergic to peanuts.
The results published in the Journal of Allergy and Clinical Immunology suggest that the molecule normally stops allergies to food developing.
The Institute of Food Research scientists said the findings offered a potential target for the prevention or treatment of food allergies.
In people who suffer from a food allergy, the immune system responds to a food protein as if it was harmful by producing antibodies.
We have identified the missing molecule that normally keeps immune responses under control and appropriate
Dr Claudio Nicoletti, study leader
In the most severe cases individuals can suffer life-threatening reactions, including anaphylactic shock.
One of the most well-known food allergies is to peanuts. This problem is becoming increasingly common, affecting one in 70 schoolchildren.
There is currently no way to treat food allergy and the only way for sufferers to manage the problem is to avoid certain foods and make sure they have injectable adrenaline at hand.
Over-stimulation
Dr Claudio Nicoletti and colleagues had already done research which showed that special types of white blood cells called dendritic cells are important in helping the immune system decide on how to respond to foreign molecules.
They found that in allergic mice the dendritic cells are much longer lasting than normal, which over-stimulates the immune system.
In the latest study, he compared the activity of dendritic cells in the gut and in the spleen of allergic and allergy-resistant mice.
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He found that in the gut of susceptible mice, dendritic cells have stopped producing interleukin-12.
Dr Nicoletti said delivering an allergen, such as peanut, alongside the interleukin-12 molecule. may help to bring allergic reactions back under control.
He is doing a further study to test this theory in mice.
“A food protein can be perfectly harmless to one person and lethal to another,” he said.
“We have identified the missing molecule that normally keeps immune responses under control and appropriate.”
Dr Nicoletti is also working with researchers in Ireland to identify whether similar characteristics can be found in human dendritic cells.
Preliminary findings suggest the dendritic cells in individuals with a food allergy are also longer lasting.
David Reading, director of the Anaphylaxis Campaign, said: “Food allergy can place an extremely heavy burden on the families affected.
“We welcome this research and look forward to further developments.”
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Posted by john on June 30th, 2007 — in Nasonex News
Israeli scientists have developed a technique for eliminating such allergies as the common cold and asthma.
Hebrew University of Jerusalem doctoral candidate Ido Bachelet has created a technique he said might become medicine’s first line of allergy therapy.
The technique focuses on mast cells — the cells that help trigger allergic reactions. Bachelet identified a mast cell receptor protein — CD300a — that has a prominent negative effect on mast cell activity, virtually shutting down the cell. But CD300a is widely found throughout the immune system and simply targeting it might result in undesired, overall immune suppression.
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To overcome that problem, Bachelet and colleague Ariel Munitz designed a small, synthetic antibody fragment that can recognize two targets simultaneously — the receptor CD300a and a mast cell-specific marker. Thus, the antibody targets CD300a only on the surface of mast cells, avoiding suppression of other immune cells.
When mice suffering from severe chronic asthma received the antibody in nose drops, they reverted to normal, healthy mice in less than two months.
The technique is being licensed by the university to pharmaceutical companies for development and eventual clinical trials.
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Posted by john on June 25th, 2007 — in Nasonex News
Researchers from Luna Innovations Incorporated (NASDAQ: LUNA) and Virginia Commonwealth University (VCU) are the first to show that carbon nanospheres, sometimes referred to as “buckyballs,” are able to block allergic response in human cell culture experiments and mice. These findings are described in a paper entitled “Fullerene Nanomaterials Inhibit the Allergic Response” published in the July 1 issue of the Journal of Immunology, setting the stage for the development of new potential therapies for allergies using nanomaterials.
Kent Murphy, CEO, Luna Innovations, noted about the immunology discovery and publication, “Luna’s collaborations with universities and strategic partners are key to our business model and we are delighted to be part of this dynamic program to discover a new frontier in medicine. We are actively seeking pharmaceutical partnerships to help us accelerate the development and validation process of these new and exciting compounds.”
Allergy is the fifth leading chronic disease in the United States among all ages, and the third most common chronic disease among children under 18 years old, according to the Asthma and Allergy Foundation of America. An estimated 50 million Americans (one in five) suffer from some type of allergy. There are currently various treatments to control allergies, but no known cure. “The immune system both protects us and causes harm, so we are always interested in finding new pathways to help manage the harmful effects,” said Chris Kepley, Ph.D., principal author on the paper and assistant professor in the Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology at the VCU School of Medicine.
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“This discovery is exciting because it points to the possibility that these novel materials can one day lead to new therapies,” said Kepley. Buckyballs, or fullerenes, are named after American architect R. Buckminster Fuller renowned for his designs based on geodesic domes. Researchers at Luna Innovations have discovered and demonstrated that therapeutic applications for fullerenes may be much more practical than previously thought or reported.
“Through this joint collaboration with VCU, we demonstrated the ability to modulate the immune response with nanoscale precision,” said Dr. Robert Lenk, President of Luna Innovations’ nanoWorks Division and co-author of the paper. “Our experiments could be the beginning of an entirely new field of medicine we are calling nanoImmunology. We are excited about the potential possibilities in immunotherapeutics and other medical disorders that may be possible with these compounds.”
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Posted by john on June 25th, 2007 — in Nasonex News
I’m not much of a cook. Once I managed to ruin a perfectly good pot while boiling water (I forgot about it until the pacifier I was sterilizing became a charred, smoking mass of plastic and latex). Back in my medical school days, I was quite content to exist for weeks at a time on peanut butter sandwiches. Nutritious, delicious and, most important, absurdly easy to prepare, they were the perfect meal. Unfortunately, for some children, peanuts are not a tasty treat but a potential threat.
Although food sensitivities get blamed for a variety of childhood problems, true food allergies are relatively uncommon. Most adverse reactions to food do not involve the immune system and are therefore more correctly referred to as food intolerance. Isolated stomachaches and other gastrointestinal disturbances are often the result of intolerance to a certain food or additive, such as milk or MSG. Children may even be able to handle a small amount of the offending substance, but a generous serving will send them scurrying for the potty.
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While stomach upset is unpleasant, true food allergies have the potential to create more serious problems. The immune-mediated response to a food may cause rash, hives, runny nose, tingling in the lips, tongue or gums, throat tightness, cough and wheezing. Extreme cases can result in anaphylaxis, a life-threatening situation that occurs when the airway squeezes shut and blood pressure drops, leading to breathing difficulty and unconsciousness.
Peanut allergies are particularly problematic, as children often require minimal contact with the food to develop symptoms, which may be disproportionately severe. Technically, peanuts are legumes (proud members of the bean family), but other nuts such as cashews and almonds have a similar allergic profile. Your doctor can refer you to an allergist who can determine specifically which foods may cause difficulty for your child.
There are a number of foods that unexpectedly contain peanuts or are manufactured in a place where nuts may lurk in the machinery, so parents with an interest in peanut allergies should check labels carefully.
Daniel had a classmate one year who was allergic to peanuts, and even with my limited abilities, I was able to read the packages and come up with acceptable snacks. It may seem like a hassle, but if it were your child who might suddenly stop breathing, you would probably appreciate the effort.
Antihistamines such as Benadryl can be given at the first sign of a reaction and may slow or stop the allergic process. If your child has a potentially severe allergy, he should always have an EpiPen close by. Minutes count, so the sooner you get epinephrine (adrenalin) into your child, the better. It’s important to have an action plan, and let teachers, friends, coaches and anybody who will be with your child when you are not around in on it.
While it used to be thought that peanut allergy was a lifelong problem, recent research indicates that 20 percent to 25 percent of children may “outgrow” it. (A much higher percentage outgrows food intolerance.) Some experts even recommend a steady dose of peanuts to prevent recurrence. Your allergist can guide you through this process.
Peanuts are the most common cause of fatal or near-fatal allergic reactions. However, with proper education, vigilant label reading and consistent access to epinephrine, your child can avoid a bad reaction. Perhaps the only meddlesome nuts in his life will be his parents.
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Posted by john on June 23rd, 2007 — in Nasonex News
Allergic disease is the sixth leading cause of chronic disease in the United States, and while various treatments have been developed to control allergy, no cure has been found. These findings advance the emerging field of medicine known as nanoimmunology.
The researchers, from Virginia Commonwealth University and Luna Innovations Inc., a private, Roanoke, Va., research company, are the first to show that buckyballs are able to block allergic response in human cell culture experiments.
Buckyballs, or fullerenes, are nanoparticles containing 60 carbon atoms. Due to their unique structure, inertness and stability, researchers from a number of scientific fields have been investigating the tiny, hollow carbon cages to serve a variety of functions. In this study, researchers modified the buckyballs so that they were compatible with water. The new study findings were published online in the June 19 issue of the Journal of Immunology and will appear in the July 1 print issue of the journal.
“This discovery is exciting because it points to the possibility that these novel materials can one day lead to new therapies,” said Chris Kepley, Ph.D., M.B.A., assistant professor in the Department of Internal Medicine, Division of Rheumatology, Allergy and Immunology at the VCU School of Medicine.
“Researchers in many fields are aware of the potential fullerenes have, however, we are the first to show they can turn off the allergic response and basic immune reactions,” he said.
According to Kepley, who is the principal author of the paper, the buckyballs are able to ‘interrupt’ the allergy/immune response by inhibiting a basic process in the cell that leads to the release of an allergic mediator. Essentially, the buckyballs are able to prevent mast cells from releasing histamine.
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Mast cells are responsible for causing allergic response and are packed with granules containing histamine. They are present in nearly all tissues except blood. When mast cells are activated, inflammatory substances such as histamine, heparin and a number of cytokines are rapidly released into the tissues and blood, promoting an allergic response.
The researchers found that the unique structure of the buckyball enables it to bind to free radicals dramatically better than any anti-oxidant currently available, such as vitamin E. Free radicals are molecules that cause oxidative stress, which experts believe may be the basis of aging.
“The immune system both protects us and causes harm, so we are always interested in finding new pathways to help manage the harmful effects,” said Kepley.
This research was supported in part by grants from the National Institutes of Health and the Food Allergy and Anaphylaxis Network.
Researchers from VCU working with Kepley included: John J. Ryan, Ph.D., from the Department of Biology; Wei Zhao, M.D., Ph.D., from the Department of Pediatrics; and Lawrence Schwartz, M.D., Ph.D., and Greg Gomez, Ph.D., from the Department of Internal Medicine.
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Posted by john on June 17th, 2007 — in Nasonex News
WALES has just one specialist to deal with one million people nationwide who are suffering from allergies.
One in three people here have some form of allergy, but with an eight-month waiting time to see Wales’ only consultant clinical immunologist, based in Cardiff, most either self-medicate or pay to be seen in private.
Experts last night warned the situation will worsen in Wales as the number of people with allergies, such as asthma and eczema, is expected to rise to as much as one in two.
“Wales is in a pretty bad situation and the number of people becoming susceptible to allergies is growing every year,” said Muriel Simmons, chief executive of national medical charity Allergy UK.
“A new report by The Royal College of Physicians suggests that one in three are sufferers and that in the next five years that’ll extend to every other person, but we believe things are already at that stage now.
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“The trouble is, with only six full-time allergy clinics in the whole of the UK - none of which are in Wales - where people can go to get tested and diagnosed, it’s difficult to get an accurate picture of the level of the problem.”
She added that the doubling of hay fever, eczema and asthma cases in the past 15 years, along with the tripling of nut allergies, was largely due to worldwide environmental changes, the presence of fewer infections that could actually result in strengthening a child’s immune system and the greater availability of a wider range of imported foods.
“Allergies have only been recognised as a speciality medicine by the Department of Health since 2000, so most GPs are not trained to deal with them and the shortage of specialists means it’s difficult for them to get expert advice,” said Ms Simmons.
“So Allergy UK has been trying to combat high consultant waiting times by running online diploma courses in allergies for doctors, nurses and other healthcare professionals. We are also looking to educate pharmacists to a higher degree so people can go along to their chemist for a consultation and a test.
“September will also see the start of an expert patient course where sufferers will be able to learn about their own allergies and how to manage them.”
Dr Paul Williams, Wales’ only consultant clinical immunologist, who’s been based at Cardiff University for the past 12 years, agreed there was an urgent need for more medics to train to deal with the hike in demand.
“We’re desperately keen to see consultants installed in both Swansea and North Wales so people won’t have to wait so long or travel so far to be seen,” he said, adding that according to the World Health Organisation half of the entire global population will suffer from one allergy or another within the next 25 years.
“There are other ways people can get help - see a dermatologist for their eczema, a respiratory physician for asthma or a gastroenterologists if they’ve got a food allergy,” he added.
“The thing is allergy sufferers have to compete for NHS funding with the likes of far more serious illnesses like cancer and there’s only so much money available - besides, no-one ever died from sneezing.”
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A spokesperson for the Welsh Assembly said: “Our current focus is on working with the Department of Health to develop national occupational standards for allergy services so that all patients with allergies have equal access to appropriate high quality care as locally as possible.
“We are taking an active role in this work with a view to one of the pilot sites being located in Wales.”
Dark side of the immune
ALLERGIES are an abnormal reaction of the body’s immune system to a substance that for most people is harmless.
Pollen, dust mite dung, pet hairs, nickel, latex and certain foods are examples of harmless substances that often cause an allergic reaction. Common allergies are hay fever, eczema, asthma and food allergies.
Allergies tend to run in families. If a person has one allergy, such as hay fever, they’re more likely to develop eczema or asthma.
Symptoms depend on the nature of the allergic disease. In hay fever, for example, there’s a stuffy nose and itchy eyes.
In serious allergic reactions, for example to peanuts or insect stings, the person’s face and throat swells, their blood pressure drops and they find it difficult to breathe. This medical emergency is called anaphylaxis.
Most allergies can’t be cured.
If symptoms still appear despite avoiding allergy triggers, antihistamine tablets, creams, nasal sprays and eye drops are available from pharmacists to relieve symptoms. Allergen immunotherapy (desensitisation) may effectively cure an allergy, but it’s a long process.
How to keep your allergies under control
Think about where you take your holidays - the seaside is an ideal destination for hay fever sufferers.
Car journeys can be improved by keeping the windows closed and some cars can be fitted with a pollen filter.
Avoid long grass during the summer months and don’t mow the lawn or weed as both can create clouds of pollen and spores.
Limit the chances of eczema by washing bedding weekly and dusting regularly with a damp cloth.
Wear wraparound sunglasses when you go outside during the hay fever season and regularly splash your eyes with cold water to soothe and cool your eyes and to help to flush out any pollen.
Check your diet - if you are prone to hay fever, you may also have a reaction to certain foods, including grain (gluten) and dairy foods, which, like pollen, contain grass proteins.
Think of the alternative - garlic can help to raise immunity, which helps the body fight the tendency to pollen allergy, while inhaling lavender, chamomile and eucalyptus essential oils are claimed to have powerful decongestant and anti-inflammatory properties.
Some believe eating royal jelly and honey - both of which are high in pollen - can help the body learn to recognise pollen and deal with it more effectively.
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Posted by john on June 13th, 2007 — in Nasonex News
6/12/2007 6:41:50 AM Vical Inc. (VICL) on Tuesday revealed the receipt of a three-year, $6.0 million grant from the National Institute of Allergy and Infectious Diseases or NIAID, as part of the National Institutes of Health, for further development of a DNA vaccine manufacturing process with the potential to produce several million doses of vaccines in a matter of days. The company noted that the RapidResponse system is designed to allow extremely rapid and large-scale production of DNA vaccines with low capital requirements, and aims at reducing the time required to develop, manufacture and deploy vaccines against emerging diseases during the early stages of an infectious outbreak.
According to the company, the RapidResponse DNA vaccine manufacturing involves a cell-free process and single-step vaccine purification, with the process having potential to be scaled up by simply using larger equipment with no increase in production time.
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ETelecare Promotes Gilbert Santa Maria To SVP Of Corporate Development - Quick Facts [ETEL]
6/12/2007 6:41:12 AM eTelecare Global Solutions Inc. (ETEL) announced that it has promoted Gilbert Santa Maria to Senior Vice President of Corporate Development. With eTelecare since 2004, Santa Maria most recently was Vice President of the Technical Support Service Line.
The company said, before joining eTelecare, Santa Maria advised D&B and other leading companies on BPO activities and was chief operating officer of a Singapore-based technology start-up. He was also general manager of Pepsi in Manila and a consultant with Booz Allen Hamilton in New York, eTelecare added.
Catapult, Testing Technologies Teams To Deliver TTCN-3 Based Conformance Test Suites - Quick Facts [CATT]
6/12/2007 6:25:32 AM Catapult Communications (CATT) on Tuesday said it entered a collaboration agreement with Testing Technologies IST GmbH agreement to jointly market TTCN-3 based conformance test suites and development tools to the telecom test market.
As per the terms of the deal, Catapult and Testing Technologies would join forces to further integrate Testing Tech’s TTCN-3 products with the DCT2000 test system and to implement a variety of marketing programs.
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Posted by john on June 10th, 2007 — in Nasonex News
Aerosol Science Laboratories Inc. has just released two new compounded medications, which are now available for nasal inhalation. Aerosol Science’s ASL Pharmacy division has added Mupirocin (active ingredient in Bactroban®) and Mometasone (active ingredient in Nasonex®) to its extensive list of compounded antibiotic, antifungal and corticosteroid aerosolized solutions for treating sinus conditions. Unlike traditional therapies, the medications from ASL are inhaled by the patient through the nose for better medication deposition into the sinuses.
Camarillo, CA (PRWEB) June 4, 2007 — Aerosol Science Laboratories Inc. has just released two new compounded medications, which are now available for nasal inhalation. Aerosol Science’s ASL Pharmacy division has added Mupirocin (active ingredient in Bactroban®) and Mometasone (active ingredient in Nasonex®) to its extensive list of compounded antibiotic, antifungal and corticosteroid aerosolized solutions for treating sinus conditions. Unlike traditional therapies, the medications from ASL are inhaled by the patient through the nose for better medication deposition into the sinuses.
Mupirocin 3.3mg/2cc is formulated to aerosolize in approximately 5-7 minutes. Mupirocin inhalation solution represents a new class of antibiotic available to physicians to treat infections caused by staphylococcus aureus and methicillin resistant staphylococcus aureus.
Mometasone 0.6mg/2cc is formulated as a very fine suspension, which aerosolizes in approximately 4 minutes. This fast treatment time is beneficial for those patients who have been prescribed more than one medication, such as an antibiotic or an antifungal along with their corticosteroid.
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Following are important benefits of inhaled sinus medications to physicians and patients:
* Most PPO insurance plans, including Medicare Part D, cover ASL Pharmacy’s aerosol therapies.
* ASL Pharmacy provides quick turnaround of Rx orders, which are shipped directly to the patient.
* Physician practices are notified when new prescriptions ship.
* ASL Pharmacy’s nasal nebulizer is fast, portable, and silent.
Aerosol Science Laboratories seeks opportunities to assist physicians with their PAR (Perennial Allergic Rhinitis), AFS (Allergic Fungal Sinusitis) and CRS (Chronic Rhinosinusitis patient cases. ASL’s Sinus Science™ therapies provide an alternative for physicians to consider when treating sinus disorders. Because inhaled medications travel directly to the site of infection, this therapy may provide better outcomes where traditional treatments have failed, without the harmful side effects of oral or intravenous drugs.
More than three hundred physicians currently refer aerosolized prescriptions to ASL Pharmacy. With over a year of operational experience formulating sinus medications exclusively, ASL has shipped over 2,000 orders in less than 12 months. According to the Center for Disease Control, there are over 32 million cases of Chronic Sinusitis annually.
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